Phenotypes Associated with This Genotype

Genotype
MGI:6279211

• Allelic Composition: Krit1^tm1Kwhi/Krit1^tm1Kwhi; Tg(Cdh5-cre/ERT2)1Rha/0
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6NCrl

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:232707 )

• almost all tamoxifen injected mice are dead by P30

cardiovascular system

abnormal brain vasculature morphology ( J:232707 , J:250906 )

• vascular malformation are first seen at P6 of tamoxifen injected mice as dilated venules in the cerebellar white matter, with numerous mature lesions present by P11 (J:232707)

• mice injected with tamoxifen at P1 exhibit cerebral cavernous malformation lesions by P13 (J:250906)

abnormal venule morphology ( J:232707 )

• tamoxifen injected mice exhibit dilated venules in the cerebellar white matter

nervous system

abnormal brain vasculature morphology ( J:232707 , J:250906 )

• vascular malformation are first seen at P6 of tamoxifen injected mice as dilated venules in the cerebellar white matter, with numerous mature lesions present by P11 (J:232707)

• mice injected with tamoxifen at P1 exhibit cerebral cavernous malformation lesions by P13 (J:250906)

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
cerebral cavernous malformation		DOID:0060669	OMIM:PS116860	J:232707 , J:250906