Phenotypes Associated with This Genotype

Genotype
MGI:6283412

• Allelic Composition: Nrg3^tm1.1Plet/Nrg3^tm1.1Plet
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:270199 )

♂N • males exhibit normal pain sensitivity in the hot plate test, no anxiety phenotype in the elevated plus maze, and no differences in MK-801-induced hyperactivity relative to wild-type controls

impaired cued conditioning behavior ( J:270199 )

♂ • males exhibit attenuated cue-dependent fear conditioning with significantly less freezing both in response to the sound on day 3 (cue-dependent conditioning) and over the entire period of the cue's presentation relative to wild-type controls

increased exploration in new environment ( J:270199 )

♂ • in an open field test, males show novelty-induced hyperactivity with significantly greater activity in the central area of the open field but no changes in peripheral or rearing activity relative to wild-type controls

♂ • however, 24-hour spontaneous locomotor activity is normal

nervous system

nervous system phenotype ( J:270199 )

♂N • males exhibit normal brain cytoarchitecture with no alterations in layering of the cortex, hippocampus or cerebellum relative to wild-type controls

reduced sensorimotor gating ( J:270199 )

♂ • males exhibit diminished prepulse inhibition (PPI) of the acoustic startle response at all prepulse intensities relative to wild-type controls

♂ • however, no differences are observed in startle magnitudes, suggesting normal startle responsiveness

decreased prepulse inhibition ( J:270199 )

♂ • males exhibit impaired PPI of the acoustic startle response

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
schizophrenia		DOID:5419	OMIM:181500	J:270199