Phenotypes Associated with This Genotype

Genotype
MGI:6287125

• Allelic Composition: Tg(tetO-DISC1*)70Plet/0; Tg(Camk2a-tTA)1Mmay/0
• Genetic Background: involves: C57BL/6 * CBA * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

abnormal spatial reference memory ( J:146881 )

♀ • spatial memory in females is impaired in probe trials, with females spending less time in the target quadrant where the platform had previously been located

increased locomotor activity ( J:146881 )

♂ • males exhibit greater spontaneous locomotor activity during the dark period of testing

abnormal social/conspecific interaction behavior ( J:146881 )

♂ • males display increased aggressiveness toward other males, with an increase in number of attacks

increased aggression towards male mice ( J:146881 )

♂ • males spend less time in social non-aggressive interaction with other males

nervous system

enlarged lateral ventricles ( J:146881 )

• volume of the lateral ventricles is increased in 9 month old mice

• however, total brain volume is normal

abnormal neuron morphology ( J:146881 )

• primary cortical neuron cultures exhibit reduced neurite complexity

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
schizophrenia 9		DOID:0070085	OMIM:604906	J:146881