Phenotypes Associated with This Genotype

Genotype
MGI:6287207

• Allelic Composition: Arhgef10^tm1.1Ssfg/Arhgef10^tm1.1Ssfg
• Genetic Background: B6.129S1-Arhgef10^tm1.1Ssfg

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:271943 )

N • mice have a normal startle reflex response and show normal spatial learning in the Morris water maze test and no obvious impulsive behaviors in the electro-foot shock aversive water drinking test (EFSDT)

increased coping response ( J:271943 )

• in the tail suspension and forced swim tests, mice exhibit significantly decreased immobility time relative to wild-type controls, indicating reduced depression-related behavior

decreased anxiety-related response ( J:271943 )

• in the elevated plus maze test, mice spend significantly more time in the open arms than wild-type controls, indicating reduced anxiety-like behavior

increased locomotor activity ( J:271943 )

• in the open field test, mice show significantly increased spontaneous locomotor activity relative to wild-type controls

• however, rearing activity and percent of activity in the center of the open field are normal

abnormal social investigation ( J:271943 )

• in the 3-chamber paradigm, mice exhibit social impairment, as they fail to spend a significantly longer time in the chamber with a stranger mouse 1 than in the empty chamber and show equal active interaction time in the chamber with the empty cylinder and stranger 1, unlike wild-type controls

abnormal response to social novelty ( J:271943 )

• in the preference for social novelty test, mice spend less time in the chamber with a novel mouse stranger 2 than in the chamber with stranger 1 and the time spent in social interactions is similar between the stranger mouse 1 and 2, unlike in wild-type controls

homeostasis/metabolism

increased dopamine level ( J:271943 )

• mice show significantly increased dopamine levels in the striatum and amygdala

• however, 3,4-Dihydroxyphenylacetic acid (DOPAC) levels are normal

increased noradrenaline level ( J:271943 )

• mice show significantly increased norepinephrine (NE) levels in the frontal cortex and amygdala

increased serotonin level ( J:271943 )

• mice show significantly increased serotonin (5-HT) levels in the frontal cortex and amygdala

• however, 5-hydroxyindoleacetic acid (5-HIAA) levels are normal

decreased monoamine oxidase activity ( J:271943 )

• protein levels of monoamine oxidase A (MAO-A) are significantly decreased in the frontal cortex and amygdala

nervous system

nervous system phenotype ( J:271943 )

N • mice exhibit no deficit in pre-pulse inhibition (PPI) relative to wild-type controls

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
autism spectrum disorder		DOID:0060041		J:271943