Phenotypes Associated with This Genotype

Genotype
MGI:6287871

• Allelic Composition: Gprasp2^tm1.1Jpe/Y
• Genetic Background: B6.129(FVB)-Gprasp2^tm1.1Jpe

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

growth/size/body

increased body weight ( J:273373 )

♂ • mice show an increase in body weight starting at 12 weeks of age

behavior/neurological

impaired spatial learning ( J:273373 )

♂ • in the Barnes maze test, mice show an increased latency to find the target during training trails and an increased latency to reach the target region during the probe trial

abnormal spatial working memory ( J:273373 )

♂ • mice show altered spontaneous alternation in the T-maze test for working memory

increased aggression towards male mice ( J:273373 )

♂ • in the tube test for social dominance, mice show a greater probability of winning by forcing a retreat of the wild-type mice out of the tube

abnormal response to novel object ( J:273373 )

♂ • in a novel object recognition test, mice show decreased time exploring and number of visits to the non-familiar object

increased grooming behavior ( J:273373 )

♂ • mice spend more time grooming

increased locomotor activity ( J:273373 )

♂ • total distance traveled in the 3-chamber social arena is greater than for controls

increased stereotypic behavior ( J:273373 )

♂ • mice spend more time in the homecage and scrabbling in the open field test

abnormal nest building behavior ( J:273373 )

♂ • innate social behavior is perturbed in the nest building test

abnormal social investigation ( J:273373 )

♂ • in the 3-chamber social arena, mice do show a preference for a social partner compared with an empty cage but their preference index for social interaction is reduced and mice spend less time overall engaging in social interaction with a novel social partner in a subsequent trial and show a lower index of preference for the novel stimulus

♂ • in a social dyadic test, mice engage in more events of non-reciprocal social interaction

nervous system

abnormal dendritic spine morphology ( J:273373 )

♂ • CA1 pyramidal neurons show a decrease in density of mature spines in apical regions, indicating impaired neuronal spine maturation

abnormal hippocampal pyramidal neuron dendrite morphology ( J:273373 )

♂ • CA1 pyramidal neurons show a reduction in dendritic arborization and a decrease in total dendritic length

abnormal postsynaptic density morphology ( J:273373 )

♂ • decrease in the thickness of postsynaptic densities in the CA1 region

decreased excitatory postsynaptic current amplitude ( J:273373 )

♂ • the amplitude of AMPA receptor-mediated miniature excitatory postsynaptic currents (mEPSCs) is reduced

♂ • however, no differences are seen in frequency of mEPSCs or in the kinetics of the miniature events

abnormal excitatory postsynaptic potential ( J:273373 )

♂ • field excitatory postsynaptic potential (fEPSP) amplitudes in the CA1 area are reduced while stimulating Shaffer collateral fibers

abnormal long-term depression ( J:273373 )

♂ • stimulation with 3,5-Dihydroxyphenylglycine (DHPG), an mGluR5 receptor agonist, promotes a long-lasting and exacerbated induction of long term depression (LTD) in the CA3-CA1 circuit compared to controls

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
autism spectrum disorder		DOID:0060041		J:273373
intellectual disability		DOID:1059		J:273373