mortality/aging
• mice die between 11 and 16 months of age
|
growth/size/body
weight loss
(
J:91795
)
• mice exhibit reduced weight towards the end of their life
|
behavior/neurological
poor grooming
(
J:91795
)
• mice exhibit poor grooming towards the end of life
|
limb grasping
(
J:91795
)
• mice exhibit hind-limb clasping when suspended by the tail towards the end of life
|
• mice exhibit hunched posture towards the end of life
|
nervous system
• mice exhibit widespread nuclear inclusions of HTT in most neurons of the CNS, however no cytoplasmic inclusions are detected
|
Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
Huntington's disease | DOID:12858 |
OMIM:143100 |
J:91795 |