Phenotypes Associated with This Genotype

Genotype
MGI:6295359

• Allelic Composition: Gnao1^tm2Rneu/Gnao1⁺
• Genetic Background: B6.129S1-Gnao1^tm2Rneu

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

decreased exploration in new environment ( J:271137 )

• both males and females show reduced activity in the first 10 min of the open field arena indicating decreased activity in a novel environment

impaired coordination ( J:271137 )

♀ • females exhibit a reduced retention time on the accelerating rotarod, while males are unaffected

♀ • however, mice do not show a difference in learning rate on the rotarod

decreased grip strength ( J:271137 )

♀ • females, but not males, show reduced forepaw grip strength

abnormal gait ( J:271137 )

• females exhibit abnormal gait with reduced stride length and increased paw angle variability while males only show increased paw angle variability

short stride length ( J:271137 )

♀ • females show reduced stride length

decreased locomotor activity ( J:271137 )

• mice exhibit reduced activity in the open field arena, with both males and females showing reduced activity in the first 10 minutes (novel environment), and females, but not males, showing reduced activity in the next 10-30 min designated as sustained activity

• both males and females show reduced total activity

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
developmental and epileptic encephalopathy 17		DOID:0080450	OMIM:615473	J:271137