Phenotypes Associated with This Genotype

Genotype
MGI:6297092

• Allelic Composition: Mlxipl^tm1Kuy/Mlxipl^tm1Kuy
• Genetic Background: B6.129S6-Mlxipl^tm1Kuy/J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

growth/size/body

weight loss ( J:273754 )

• mice exhibit a significant weight loss when fed a high fructose diet (60% fructose, 10% starch), showing a 20% reduction in body weight after 5 days on the diet

• body weight recovers within 6 days after switching back to the control diet

digestive/alimentary system

diarrhea ( J:273754 )

• mice fed a high fructose diet develop severe diarrhea

increased cecum weight ( J:273754 )

• cecum weight is increased in mice fed a high fructose diet

distended cecum ( J:273754 )

• on day 3 of a high fructose diet, mice exhibit enlarged ceca that contains fluid

• by day 5 and through day 7 of the high fructose diet, mice exhibit enlarged, red intestines and extremely distended ceca that contain both fluid and gas

increased colon length ( J:273754 )

• colon length is increased in mice fed a high fructose diet

decreased defecation amount ( J:273754 )

• fecal pellets are decreased in high fructose fed mice

abnormal intestinal fructose absorption ( J:273754 )

• fructose levels in feces are 2-fold higher in mice fed a high fructose diet, indicating development of fructose intolerance

• plasma alanine transaminase, aspartate transaminase, and lactate dehydrogenase, indicators of liver injury, are not increased in mutant mice fed a high fructose diet unlike in wild-type mice that show an increase in their levels, indicating resistance to liver damage by high fructose diet due to impaired fructose absorption

• on the high fructose diet, lactate levels in the intestine are not increased as in wild-type mice and lactate levels in the liver are decreased in mutants indicating impaired fructose conversion into lactate in the intestine but not the liver

behavior/neurological

decreased food intake ( J:273754 )

• average daily food intake is lower in mice fed a high fructose diet

• food intake is decreased by more than 50% within 1-2 days after starting the high fructose diet and increases right after switching back to the control diet

homeostasis/metabolism

decreased circulating glucose level ( J:273754 )

♂ • males exhibit a lower blood glucose levels when fed a high fructose diet

increased circulating glucose level ( J:273754 )

♀ • females exhibit a slight increase in blood glucose levels when fed a high fructose diet

decreased circulating cholesterol level ( J:273754 )

• plasma cholesterol levels are decreased in mutant mice on both a control diet and the high fructose diet

decreased circulating triglyceride level ( J:273754 )

• plasma triglyceride levels are decreased in mutant mice on both a control diet and the high fructose diet

decreased body temperature ( J:273754 )

• mice exhibit lower body temperature when fed a high fructose diet

decreased liver triglyceride level ( J:273754 )

• liver triglyceride levels are decreased in mutant mice on both a control diet and the high fructose diet

liver/biliary system

decreased liver triglyceride level ( J:273754 )

• liver triglyceride levels are decreased in mutant mice on both a control diet and the high fructose diet

mortality/aging

premature death ( J:273754 )

• mice fed a high fructose diet become moribund in 2 weeks

• mice younger than 5 weeks that are fed the high fructose diet become moribund within a few days

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
irritable bowel syndrome		DOID:9778		J:273754