Phenotypes Associated with This Genotype

Genotype
MGI:6303631

cn1

• Allelic Composition: Atp6v0a2^tm1Kdb/Atp6v0a2^tm1Kdb; Tg(MMTV-cre)4Mam/0
• Genetic Background: involves: 129 * C57BL/6 * FVB

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

endocrine/exocrine glands

abnormal mammary gland development ( J:274047 )

♀ • glands from pubertal mice show delayed ductal outgrowth

impaired mammary gland growth during pregnancy ( J:274047 )

♀ • early pregnant mammary glands show decreased ductal elongation, bifurcation and tertiary branching

abnormal mammary gland epithelium morphology ( J:274047 )

♀ • mice and exhibit a disintegrated mammary epithelium, with a decrease in mammary epithelial content and in myoepithelial cells

abnormal mammary gland duct morphology ( J:274047 )

♀ • at puberty, mice show a decrease in relative ductal length

♀ • during early pregnancy, mice show decreased ductal elongation

abnormal branching of the mammary ductal tree ( J:274047 )

♀ • early pregnant mammary glands show decreased bifurcation and tertiary branching

abnormal mammary duct terminal end bud morphology ( J:274047 )

♀ • mice show a decrease in the number of terminal end buds and ductal branches

abnormal lactation ( J:274047 )

♀ • mice exhibit a decrease in expression of beta-casein, a lactation marker, and litters from mutant mice have lower body weight than litters from wild-type mice, suggesting abnormal lactation

integument

abnormal mammary gland development ( J:274047 )

♀ • glands from pubertal mice show delayed ductal outgrowth

impaired mammary gland growth during pregnancy ( J:274047 )

♀ • early pregnant mammary glands show decreased ductal elongation, bifurcation and tertiary branching

abnormal mammary gland epithelium morphology ( J:274047 )

♀ • mice and exhibit a disintegrated mammary epithelium, with a decrease in mammary epithelial content and in myoepithelial cells

abnormal mammary gland duct morphology ( J:274047 )

♀ • at puberty, mice show a decrease in relative ductal length

♀ • during early pregnancy, mice show decreased ductal elongation

abnormal branching of the mammary ductal tree ( J:274047 )

♀ • early pregnant mammary glands show decreased bifurcation and tertiary branching

abnormal mammary duct terminal end bud morphology ( J:274047 )

♀ • mice show a decrease in the number of terminal end buds and ductal branches

abnormal lactation ( J:274047 )

♀ • mice exhibit a decrease in expression of beta-casein, a lactation marker, and litters from mutant mice have lower body weight than litters from wild-type mice, suggesting abnormal lactation

reproductive system

impaired mammary gland growth during pregnancy ( J:274047 )

♀ • early pregnant mammary glands show decreased ductal elongation, bifurcation and tertiary branching