Phenotypes Associated with This Genotype

Genotype
MGI:6313621

• Allelic Composition: Tg(Itgam-FCAR)83Rcmo/0
• Genetic Background: involves: C57BL/6 * NOD

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

renal/urinary system

albuminuria ( J:120534 )

• mice exhibit albuminuria at 24 weeks of age

hematuria ( J:120534 )

• mice exhibit spontaneous microscopic hematuria after 18 weeks of age

glomerulonephritis ( J:120534 )

• focal and segmental lesions with glomerular hypertrophy, mesangial matrix expansion without cellular proliferation, congested glomerular capillary, and moderate interstitial cell infiltration focally condensed around glomeruli in 24-week old mice

• marked infiltration by mac-1+ mononuclear cells is seen in the intra- and periglomerular regions surrounding the Bowman space, indicating the presence of macrophages in and around damaged glomeruli

abnormal glomerular mesangium morphology ( J:120534 )

• kidneys show massive mesangial IgA deposition at 24 weeks of age

expanded mesangial matrix ( J:120534 )

renal glomerulus hypertrophy ( J:120534 )

abnormal kidney interstitium morphology ( J:120534 )

• interstitial macrophage infiltration

hematopoietic system

increased IgA level ( J:120534 )

• kidneys show massive mesangial IgA deposition at 24 weeks of age

• IgA deposits are seen as early as 12 weeks of age

homeostasis/metabolism

albuminuria ( J:120534 )

• mice exhibit albuminuria at 24 weeks of age

hematuria ( J:120534 )

• mice exhibit spontaneous microscopic hematuria after 18 weeks of age

immune system

increased IgA level ( J:120534 )

• kidneys show massive mesangial IgA deposition at 24 weeks of age

• IgA deposits are seen as early as 12 weeks of age

glomerulonephritis ( J:120534 )

• focal and segmental lesions with glomerular hypertrophy, mesangial matrix expansion without cellular proliferation, congested glomerular capillary, and moderate interstitial cell infiltration focally condensed around glomeruli in 24-week old mice

• marked infiltration by mac-1+ mononuclear cells is seen in the intra- and periglomerular regions surrounding the Bowman space, indicating the presence of macrophages in and around damaged glomeruli

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
IgA glomerulonephritis		DOID:2986	OMIM:161950	J:120534