Phenotypes Associated with This Genotype

Genotype
MGI:6315641

• Allelic Composition: Grm5^tm1Rod/Grm5^tm1Rod
• Genetic Background: B6.129-Grm5^tm1Rod

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

abnormal associative learning ( J:268239 )

♂ • mice exhibit impaired pairwise visual discrimination, requiring more trials to reach criterion, performing more correction trials, and increased preservation index

impaired learning ( J:268239 )

♂ • mice are impaired on early reversal learning, taking more trials to reach criterion and requiring more correction trials overall and when adjusting for other factors and exhibit this similar phenotype on late reversal learning

♂ • mice are impaired at extinction, responding at a higher rate throughout the extinction sessions

♂ • mice show no differences in locomotor activity, reward collection time or latency to touch stimuli across reversal learning

impaired discrimination learning ( J:268239 )

♂ • mice exhibit impaired pairwise visual discrimination, requiring more trials to reach criterion, performing more correction trials, and increased preservation index

♂ • mice show no differences in locomotor activity, reward collection time or latency to touch stimuli across visual discrimination

cognitive inflexibility ( J:268239 )

♂ • mice are impaired on early reversal learning, taking more trials to reach criterion and requiring more correction trials overall and when adjusting for other factors and exhibit this similar phenotype on late reversal learning

♂ • mice are impaired at extinction, responding at a higher rate throughout the extinction sessions

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
schizophrenia		DOID:5419	OMIM:181500	J:268239