Phenotypes Associated with This Genotype

Genotype
MGI:6315869

• Allelic Composition: Lztr1^{tm1a(EUCOMM)Wtsi}/Lztr1⁺
• Genetic Background: involves: C57BL/6N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:268690 )

• mice exhibit reduced longevity, with reduced survival beginning around 20 weeks of age

growth/size/body

cardiac hypertrophy ( J:268690 )

• eccentric hypertrophy

abnormal facial morphology ( J:268690 )

♂ • males exhibit facial dysmorphia

broad nasal bone ( J:268690 )

• increase in nasal bone width

decreased body weight ( J:268690 )

♂ • males exhibit decreased weight

craniofacial

decreased cranium height ( J:268690 )

♂ • shorter skull length in males

increased cranium width ( J:268690 )

• increase in skull width

short parietal bone ( J:268690 )

• decrease in parietal bone length

abnormal facial morphology ( J:268690 )

♂ • males exhibit facial dysmorphia

broad nasal bone ( J:268690 )

• increase in nasal bone width

cardiovascular system

increased myocardial fiber size ( J:268690 )

• increase in cardiomyocyte area

cardiac hypertrophy ( J:268690 )

• eccentric hypertrophy

increased cardiac stroke volume ( J:268690 )

♀ • increase in stroke volume in females

decreased cardiac muscle contractility ( J:268690 )

♂ • decrease in % ejection fraction and fractional shortening in males

abnormal heart echocardiography feature ( J:268690 )

• echocardiography indicates decreased left ventricular systolic function and increased diastolic dimensions

cellular

increased cell proliferation ( J:268690 )

• MEFs exhibit increased growth rate

muscle

increased myocardial fiber size ( J:268690 )

• increase in cardiomyocyte area

decreased cardiac muscle contractility ( J:268690 )

♂ • decrease in % ejection fraction and fractional shortening in males

skeleton

decreased cranium height ( J:268690 )

♂ • shorter skull length in males

increased cranium width ( J:268690 )

• increase in skull width

short parietal bone ( J:268690 )

• decrease in parietal bone length

broad nasal bone ( J:268690 )

• increase in nasal bone width

respiratory system

broad nasal bone ( J:268690 )

• increase in nasal bone width

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Noonan syndrome 10		DOID:0060588	OMIM:616564	J:268690