Phenotypes Associated with This Genotype

Genotype
MGI:6317327

• Allelic Composition: Pkd1^tm2Som/Pkd1^tm2Som; Tg(Cdh16-cre)91Igr/0
• Genetic Background: involves: 129S4/SvJae * C57BL/6 * ICR

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:244067 )

• median survival is 14 days, with mice starting to die around 10 days and most die by 20 days of age

renal/urinary system

increased kidney cell proliferation ( J:244067 )

• increase in cyst epithelial cell proliferation

polycystic kidney ( J:244067 )

• mice develop an early-onset and rapidly fatal form of polycystic kidney disease

cellular

increased kidney cell proliferation ( J:244067 )

• increase in cyst epithelial cell proliferation

homeostasis/metabolism

increased circulating creatinine level ( J:244067 )

growth/size/body

polycystic kidney ( J:244067 )

• mice develop an early-onset and rapidly fatal form of polycystic kidney disease

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
polycystic kidney disease 1		DOID:0110858	OMIM:173900	J:244067