Phenotypes Associated with This Genotype

Genotype
MGI:6324047

• Allelic Composition: Shank3^tm2Gfng/Shank3⁺
• Genetic Background: B6.129-Shank3^tm2Gfng/J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

impaired discrimination learning ( J:243083 )

• in the touchscreen pairwise discrimination task, mice are slower to reach criterion and exhibit trends toward making more errors (first trial errors) and more correction errors than wild-type mice

• however, mice exhibit normal open field activity and sociability in the three chamber test

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
autism spectrum disorder		DOID:0060041		J:243083
Phelan-McDermid syndrome		DOID:0080354	OMIM:606232	J:243083