Phenotypes for Atp7a MGI:6324210 MGI Mouse

homeostasis/metabolism

• mice show a decrease in cadmium content in the skin and connective tissue compared to wild-type mice following injection of isotope-labeled cadmium

• however, levels of cadmium in organs such as kidney, liver, and lung are similar to wild-type mice and zinc levels are normal in these organs and in skin and connective tissue

abnormal copper homeostasis ( J:36268 )

• mice show an increase in copper content in the kidney, skin, and connective tissues, with a smaller increase in lungs but no change in duodenal levels compared to wild-type mice following injection of isotope-labeled copper

• mice show a decrease in copper accumulation in the liver and a small decrease in brain copper content

decreased brain copper level ( J:36268 )

• mice show a small decrease in brain copper content compared to wild-type mice following injection of isotope-labeled copper

increased kidney copper level ( J:36268 )

• mice show an increase in accumulation of copper in the kidney compared to wild-type mice following injection of isotope-labeled copper

decreased liver copper level ( J:36268 )

• mice show a decrease in copper accumulation in the liver compared to wild-type mice following injection of isotope-labeled copper

liver/biliary system