Phenotypes for Atp7a MGI:6324231 MGI Mouse

growth/size/body

abnormal postnatal growth ( J:1132 )

• males exhibit decreased body weight at 10 and 14 days of age but not at 10 days indicating decreased postnatal growth

• treatment with copper does not affect body weight

pigmentation

absent coat pigmentation ( J:12745 )

• white fur

behavior/neurological

ataxia ( J:12745 )

• mild ataxia in 10 day old mice

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:1132 )

N	• urate oxidase activity in the liver is normal

increased intestine copper level ( J:12745 )

• copper content in the small and large intestine is increased

increased kidney copper level ( J:12745 )

decreased copper level ( J:12745 )

• copper content in the heart is decreased

decreased brain copper level ( J:12745 )

• copper content in the cerebrum, cerebellum and brain stem is decreased

decreased brainstem copper level ( J:12745 )

decreased liver copper level ( J:1132 , J:12745 )

• liver copper content is decreased in 7 to 14 day old males (J:1132)

• treatment with copper increases liver copper content (J:1132)

(J:12745)

abnormal enzyme/coenzyme activity ( J:12745 )

• cytochrome c oxidase activity in the brain (cerebrum, cerebellum, brain stem) and heart is decreased

• however, cytochrome c oxidase activity in the lung, spleen, thymus, intestine, kidney and liver is not affected

digestive/alimentary system

abnormal large intestine morphology ( J:12745 )

• large intestine weight is lower in 10 day old mice

• copper treatment increases large intestine weight

hematopoietic system

decreased spleen weight ( J:12745 )

• spleen weight is lower in 10 day old mice

• copper treatment increases spleen weight

liver/biliary system