Phenotypes Associated with This Genotype

Genotype
MGI:6324924

• Allelic Composition: Camk2a^em1Rjco/Camk2a^em1Rjco
• Genetic Background: involves: C57BL/6J * DBA/2J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

decreased exploration in new environment ( J:239596 )

• mice exhibit decreased marble burying behavior, suggesting reduced exploration in a complex environment

increased thigmotaxis ( J:239596 )

• mice spend less time in the center of the open field arena than wild-type mice, indicating increased anxiety

hyperactivity ( J:239596 )

• mice are hyperactive in a novel open field arena

increased vertical activity ( J:239596 )

• mice exhibit increased rearing and jumping in the open field and these behaviors are persistent across the entire test period, indicating repetitive behavior

circling ( J:239596 )

• mice exhibit increased repetitive rotational behavior in the 3-chamber social assay

abnormal social/conspecific interaction behavior ( J:239596 )

• mice exhibit a deficit in social motivation as indicated by increased circling in the 3-chamber social assay

• however, no deficits in preference for social novelty is seen

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
autism spectrum disorder		DOID:0060041		J:239596