Phenotypes Associated with This Genotype

Genotype
MGI:6331093

• Allelic Composition: Tg(Thy1-DCTN1*G71A)#Ytsu/0
• Genetic Background: involves: C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

decreased exploration in new environment ( J:258003 )

• 6 month old mice show fewer line-crossings and less rearing in the open-field test, suggesting lower exploratory activity

impaired coordination ( J:258003 )

• 16 month old mice show shorter latencies to fall off the rotarod when high rotation speeds are used but show similar fall latencies as wild-type mice at low and moderate rotation speeds and at 6 months of age

decreased vertical activity ( J:258003 )

• 6 month old mice show less rearing in the open-field test

nervous system

nervous system phenotype ( J:258003 )

N • neuronal loss or gliosis are not seen in the brain and no TDP-43 aggregates are detected in the substantia nigra or cerebral cortex

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Perry syndrome		DOID:0060486	OMIM:168605	J:258253