Analysis Tools
craniofacial
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• about 80% of tamoxifen-treated mice exhibit increased nasal air space due to remodeling of the nasal cavity
• nasal air space increases over time and is significant at 2 and 3 months after tamoxifen treatment
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• about 80% of tamoxifen-treated mice develop mucus plugging in multiple nasal cavities
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growth/size/body
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• about 80% of tamoxifen-treated mice exhibit increased nasal air space due to remodeling of the nasal cavity
• nasal air space increases over time and is significant at 2 and 3 months after tamoxifen treatment
|
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• about 80% of tamoxifen-treated mice develop mucus plugging in multiple nasal cavities
|
nervous system
hydrocephaly
(
J:277289
)
|
• about 3% of tamoxifen-treated mice exhibit hydrocephalus
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respiratory system
|
• about 80% of tamoxifen-treated mice exhibit increased nasal air space due to remodeling of the nasal cavity
• nasal air space increases over time and is significant at 2 and 3 months after tamoxifen treatment
|
|
• about 80% of tamoxifen-treated mice develop mucus plugging in multiple nasal cavities
|
|
• mucociliary clearance is impaired in tamoxifen-treated mice, with impairment of clearance correlated with changes in nasal air space and presence of mucus in the nose
• effective speed of mucociliary clearance is slower and the directionality of the flow is affected in tamoxifen-treated mice with increased nasal air space and mucus accumulation
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| primary ciliary dyskinesia | DOID:9562 |
OMIM:PS244400 |
J:277289 | |
