Phenotypes Associated with This Genotype

Genotype
MGI:6356707

• Allelic Composition: Myh6^tm3.1Jse/Myh6⁺
• Genetic Background: involves: 129

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

myocardial fiber disarray ( J:247162 )

• myofiber disarray at 26 weeks of age

cardiac hypertrophy ( J:247162 )

• progressive concentric hypertrophy

thick ventricular wall ( J:247162 )

• left ventricular wall thickness is more than 20% greater than in wild-type mice at 26 weeks of age

cardiac interstitial fibrosis ( J:247162 )

• interstitial fibrosis at 26 weeks of age

increased cardiac muscle contractility ( J:247162 )

• % ejection fraction is increased

abnormal heart echocardiography feature ( J:247162 )

• echocardiography indicates increased left ventricular anterior wall thickness, left ventricular posterior wall thickness, and increased % ejection fraction

growth/size/body

cardiac hypertrophy ( J:247162 )

• progressive concentric hypertrophy

muscle

myocardial fiber disarray ( J:247162 )

• myofiber disarray at 26 weeks of age

increased cardiac muscle contractility ( J:247162 )

• % ejection fraction is increased

cellular

cardiac interstitial fibrosis ( J:247162 )

• interstitial fibrosis at 26 weeks of age

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
hypertrophic cardiomyopathy 14		DOID:0110320	OMIM:613251	J:247162