Phenotypes Associated with This Genotype

Genotype
MGI:6356708

ht2

• Allelic Composition: Myh6^tm1.1Jpsc/Myh6⁺
• Genetic Background: involves: 129

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

cardiovascular system phenotype ( J:247162 )

N • end-diastolic left ventricular anterior wall thickness and dimensions, as well as fractional shortening are normal at 26 weeks of age and 8 week old mice show normal left ventricular pressures, contraction and relaxation

N • hearts show no detectable morphological differences at 78 weeks of age

cardiac hypertrophy ( J:247162 )

• treatment with cyclosporine exacerbates the hypertrophic response, with mice developing symmetrical left ventricular wall thickening after 3 weeks of treatment

homeostasis/metabolism

increased physiological sensitivity to xenobiotic ( J:247162 )

• treatment with cyclosporine exacerbates the hypertrophic response, with mice developing symmetrical left ventricular wall thickening after 3 weeks of treatment

growth/size/body

cardiac hypertrophy ( J:247162 )

• treatment with cyclosporine exacerbates the hypertrophic response, with mice developing symmetrical left ventricular wall thickening after 3 weeks of treatment