Phenotypes Associated with This Genotype

Genotype
MGI:6357992

hm1

• Allelic Composition: Vgll2^tm1Tm/Vgll2^tm1Tm
• Genetic Background: involves: 129S2/SvPas * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

impaired exercise endurance ( J:258195 )

• homozygous mice were able to run on a treadmill for a significantly shorter time and distance than controls

muscle

abnormal skeletal muscle fiber type ratio ( J:258195 )

• in soleus muscle, both type I and type IIa fibers were reduced, and an obvious increase in type IIb fibers was detected in homozygous mice

• in extensor digitorum longus (EDL) muscle, myosin electrophoretogram showed that fast type IIa and IIx myosin were predominantly replaced by the fastest type IIb myosin

homeostasis/metabolism

impaired exercise endurance ( J:258195 )

• homozygous mice were able to run on a treadmill for a significantly shorter time and distance than controls