Phenotypes Associated with This Genotype

Genotype
MGI:6358593

• Allelic Composition: Dlgap4^Gt(XH723)Byg/Dlgap4^Gt(XH723)Byg
• Genetic Background: B6.129P2-Dlgap4^Gt(XH723)Byg

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

abnormal learning/memory/conditioning ( J:277713 )

abnormal habituation to a new environment ( J:277713 )

• do not show short-term (within session) habituation in an open field test

decreased exploration in new environment ( J:277713 )

• the number of rearing bouts was reduced in an open field

impaired spatial learning ( J:277713 )

• in a water maze based on poor performance during learning and probe trials

abnormal spatial working memory ( J:277713 )

• in a water maze based on poor performance during learning and probe trials

decreased anxiety-related response ( J:277713 )

• high-preference for spending time in the open versus closed arms and spend less time in the center of the maze in an elevated plus maze

• however, no change in thigmotactic behavior is seen in an open field

decreased grooming behavior ( J:277713 )

• self-grooming was seen in only 1 of 6 mice compared to 6 of 6 wild-type controls

abnormal motor coordination/balance ( J:277713 )

• in an elevated plus maze more homozygotes fall from the open arms compared to wild-type controls

• fail to display the typical flat posture when walking on an elevated open arm for the first time

abnormal posture ( J:277713 )

• spend less time in a posture indicative conflictual state and arousal

increased locomotor activity ( J:277713 )

• increase in the distance traveled in an open field test

• increase in the number of arm crossings in an elevated plus maze

• increase in dark phase locomotor activity in the home cage

abnormal social/conspecific interaction behavior ( J:277713 )

• decrease in the time spent engaged in social interactions

abnormal response to social novelty ( J:277713 )

• decrease in time spent in social interactions and vocalizations is particularly decreased during the first minute of an encounter with another juvenile mouse

• adults spend less time sniffing an intruder male or female mouse due to shorter average approach times

social withdrawal ( J:277713 )

decreased vocalization ( J:277713 )

• in juvenile mice during a direct reciprocal social interaction in same genotype pairs

nervous system

abnormal nervous system electrophysiology ( J:277713 )

• increase in the amplitude and decrease in the duration of oscillatory events

abnormal excitatory postsynaptic currents ( J:277713 )

• significant decrease in the relative amount of GluN2A-mediated NMDAR evoked excitatory postsynaptic currents in CA1 pyramidal cells

abnormal miniature excitatory postsynaptic currents ( J:277713 )

• significant increase in the average amplitudes but average half width and frequency are similar to controls

reduced long-term depression ( J:277713 )

• long term depression induced by low frequency stimulation is impaired in hippocampal CA1 pyramidal cell synapses

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
autism spectrum disorder		DOID:0060041		J:277713