Phenotypes Associated with This Genotype

Genotype
MGI:6360225

• Allelic Composition: Mrtfb^em1Dsr/Mrtfb⁺; Myh7^em1Dsr/Myh7⁺; Nkx2-5^em1Dsr/Nkx2-5⁺
• Genetic Background: involves: C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

abnormal trabecula carnea morphology ( J:277399 )

• mice exhibit deep trabeculations in the left ventricular wall at P3

• mice show a significant difference in trabecular complexity compared to controls

thin ventricular wall ( J:277399 )

• decrease in the apical wall thickness

• however, no changes in left ventricular free wall thickness

increased response of heart to induced stress ( J:277399 )

• mice exhibit a reduction in cardiac function after transverse aortic constriction compared to wild-type mice, with incomplete penetrance

• however, cardiac function by echocardiography is normal at baseline in adult mice

homeostasis/metabolism

increased response of heart to induced stress ( J:277399 )

• mice exhibit a reduction in cardiac function after transverse aortic constriction compared to wild-type mice, with incomplete penetrance

• however, cardiac function by echocardiography is normal at baseline in adult mice

muscle

abnormal trabecula carnea morphology ( J:277399 )

• mice exhibit deep trabeculations in the left ventricular wall at P3

• mice show a significant difference in trabecular complexity compared to controls

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
left ventricular noncompaction		DOID:0060480	OMIM:604169	J:277399