Phenotypes Associated with This Genotype

Genotype
MGI:6363217

• Allelic Composition: Mrap^tm1.2Geno/Mrap^tm1.2Geno
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

neonatal lethality, incomplete penetrance ( J:278935 )

• mice are found dead before P0.5 without milk in their stomach

• however, corticosterone replacement rescues lethality

postnatal lethality, incomplete penetrance ( J:278935 )

• only 3 mice survive to weaning

• however, corticosterone replacement rescues lethality

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:278935 )

N • male mice exhibit normal aldosterone, epinephrine and norepinephrine serum levels

N • male and female mice exhibit normal levels of aldosterone

decreased circulating corticosterone level ( J:278935 )

♂ • not detectable at baseline and in response to ACTH in male mice

decreased liver glycogen level ( J:278935 )

• at E19.5

increased adrenocorticotropin level ( J:278935 )

♂ • in male mice

endocrine/exocrine glands

abnormal adrenal gland capsule morphology ( J:278935 )

• thickened due to increased cell numbers at E19.5 and 8 weeks in mice that is partially rescued by corticosterone replacement

abnormal adrenal gland development ( J:278935 )

• impaired progenitor cell differentiation

small adrenal glands ( J:278935 )

respiratory system

impaired lung alveolus development ( J:278935 )

• resembling immature lungs prior to terminal differentiation of the alveoli in mice that die before P0.5

primary atelectasis ( J:278935 )

behavior/neurological

absent gastric milk in neonates ( J:278935 )

liver/biliary system

decreased liver glycogen level ( J:278935 )

• at E19.5

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
adrenal gland disease		DOID:9553		J:278935