Phenotypes Associated with This Genotype

Genotype
MGI:6376530

• Allelic Composition: Cd79a^tm1(cre)Reth/Cd79a⁺; Inpp5d^tm1Rav/Inpp5d^tm1Rav
• Genetic Background: involves: 129 * BALB/c * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:178833 )

• mice have a less than 40% survival rate at 1 year

immune system

increased IgG level ( J:178833 )

• IgG deposition in kidney glomeruli is seen at 20 weeks of age

increased susceptibility to systemic lupus erythematosus ( J:178833 )

• mice show autoantibodies that are specifically seen in lupus; ssDNA, dsDNA, dsRNA and chromatin

increased autoantibody level ( J:178833 )

increased anti-nuclear antigen antibody level ( J:178833 )

• anti-nuclear antibodies in the sera in 20-week old mice

increased anti-chromatin antibody level ( J:178833 )

• mice exhibit chromatin autoantibodies at 8 weeks of age and at 20 weeks of age, mice show chromatin antibodies at amounts comparable to those seen in NZB/NZW mice

increased anti-double stranded DNA antibody level ( J:178833 )

increased anti-single stranded DNA antibody level ( J:178833 )

hematopoietic system

increased IgG level ( J:178833 )

• IgG deposition in kidney glomeruli is seen at 20 weeks of age

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
systemic lupus erythematosus		DOID:9074	OMIM:152700 OMIM:300809 OMIM:605480 OMIM:608437 OMIM:609903 OMIM:609939 OMIM:610065 OMIM:610066 OMIM:612254 OMIM:612378 OMIM:613145 OMIM:614420	J:178833