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Phenotypes Associated with This Genotype
Genotype
MGI:6378447
Allelic
Composition
Col1a1tm1(tetO-URI1)Ndj/Col1a1tm1(tetO-URI1)Ndj
Tg(Cebpb-tTA)#Bjd/0
Genetic
Background
B6.Cg-Col1a1tm1(tetO-URI1)Ndj Tg(Cebpb-tTA)#Bjd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Col1a1tm1(tetO-URI1)Ndj mutation (0 available); any Col1a1 mutation (161 available)
Tg(Cebpb-tTA)#Bjd mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
liver/biliary system
• mice develop hepatocellular carcinoma by 10 weeks of age
• mice kept on doxycycline until 8 weeks of age and then transferred to normal chow develop liver tumors
• 3 week old mice mice supplied with a nicotinamide riboside diet show prevention of liver tumors at 30 weeks of age
• 12 week old mice with tumors supplied with a nicotinamide riboside diet for 48 weeks show tumor regression

neoplasm
• mice develop hepatocellular carcinoma by 10 weeks of age
• mice kept on doxycycline until 8 weeks of age and then transferred to normal chow develop liver tumors
• 3 week old mice mice supplied with a nicotinamide riboside diet show prevention of liver tumors at 30 weeks of age
• 12 week old mice with tumors supplied with a nicotinamide riboside diet for 48 weeks show tumor regression

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
hepatocellular carcinoma DOID:684 OMIM:114550
J:217463


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
07/02/2024
MGI 6.13
The Jackson Laboratory