Phenotypes Associated with This Genotype

Genotype
MGI:6378452

cx3

• Allelic Composition: Col1a1^{tm1(tetO-URI1)Ndj}/Col1a1⁺; Tg(Cebpb-tTA)#Bjd/0; Trp53^tm1Gev/Trp53⁺
• Genetic Background: B6.Cg-Trp53^tm1Gev Col1a1^{tm1(tetO-URI1)Ndj} Tg(Cebpb-tTA)#Bjd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:217463 )

• mice exhibit reduced survival compared to heterozygous Col1a1^{tm1(tetO-URI1)Ndj} Tg(Cebpb-tTA)#Bjd/0 mice

neoplasm

increased hepatocellular carcinoma incidence ( J:217463 )

• mice exhibit accelerated liver tumorigenesis compared to single heterozygous Col1a1^{tm1(tetO-URI1)Ndj} Tg(Cebpb-tTA)#Bjd/0 mice, with 80% of mice showing aggressive hepatocellular carcinoma

liver/biliary system

decreased hepatocyte apoptosis ( J:217463 )

• 8 week old mice show decreased cleaved caspase 3, Bax expression, collapsed fibers, Sirius Red staining and alanine transaminase levels, indicating suppressed hepatocyte apoptosis

increased hepatocellular carcinoma incidence ( J:217463 )

• mice exhibit accelerated liver tumorigenesis compared to single heterozygous Col1a1^{tm1(tetO-URI1)Ndj} Tg(Cebpb-tTA)#Bjd/0 mice, with 80% of mice showing aggressive hepatocellular carcinoma

cellular

decreased hepatocyte apoptosis ( J:217463 )

• 8 week old mice show decreased cleaved caspase 3, Bax expression, collapsed fibers, Sirius Red staining and alanine transaminase levels, indicating suppressed hepatocyte apoptosis