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Phenotypes Associated with This Genotype
Genotype
MGI:6381653
cx2
Allelic
Composition
Prdm11tm1.1Ahl/Prdm11tm1.1Ahl
Tg(IghMyc)22Bri/0
Genetic
Background
B6.Cg-Prdm11tm1.1Ahl Tg(IghMyc)22Bri
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Prdm11tm1.1Ahl mutation (0 available); any Prdm11 mutation (22 available)
Tg(IghMyc)22Bri mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
neoplasm
• mice show accelerated development of B-cell lymphomas, with a median survival of 94 days versus 113 days in single Tg(IghMyc)22Bri mice
• however, no difference in tumor load or in proliferation are seen and no differences in cell cycle profiles or apoptotic index are seen


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/18/2025
MGI 6.24
The Jackson Laboratory