Phenotypes Associated with This Genotype

Genotype
MGI:6388457

• Allelic Composition: Ngf^tm1(NGF*)Cat/Ngf^tm1(NGF*)Cat
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:282017 , J:284096 )

• mice die by P30 (J:282017)

• mice die by the first month of life (J:284096)

• treatment of pregnant dams and pups with mouse NGF (from beginning of gestation until 10 days post-delivery followed by intranasal and subcutaneous NGF administration to pups) fully rescues the early lethality (J:284096)

growth/size/body

decreased body weight ( J:284096 )

• body weight at P15, but not at birth, is lower

• administration of mouse NGF restores body weight for the first 2 weeks

nervous system

abnormal striatum morphology ( J:284096 )

• density of ChAT+ neurons in the striatum is increased

abnormal cholinergic neuron morphology ( J:284096 )

• density of ChAT+ neurons in the striatum is increased

• however, density of ChAT+ neurons in the basal forebrain (medial septum and nucleus basalis of Meynert) are unchanged

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
hereditary sensory and autonomic neuropathy type 5		DOID:0070145	OMIM:608654	J:284096