mortality/aging
• minor decrease in survival
|
• minor decrease in survival
|
cardiovascular system
• descending thoracic aortae show dilation
|
• approximately 1.2-fold increase in heart weight
|
• echocardiography shows left ventricle dilation, and increased cardiac output and stroke volume
• however, fractional shortening is not different
|
hypotension
(
J:281903
)
• basal systolic and diastolic blood pressures are decreased in anesthetized mice
• the blood-pressure lowering effect of pinacidil is reduced
|
• reduction in vessel contractility
• passive vessel compliance is increased
|
• basal K
|
• carotid arterial diameters across a full range of physiological pressures are increased, indicating dilated, compliant arterial vessels
|
muscle
• basal K
|
• carotid arterial diameters across a full range of physiological pressures are increased, indicating dilated, compliant arterial vessels
|
nervous system
• enhanced basal K(ATP) conductance in vascular smooth muscle
• reduced ATP sensitivity of ventricular myocyte K(ATP) channels
|
growth/size/body
• approximately 1.2-fold increase in heart weight
|
Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
hypertrichotic osteochondrodysplasia Cantu type | DOID:0060569 |
OMIM:239850 |
J:281903 |