Phenotypes Associated with This Genotype

Genotype
MGI:6393415

• Allelic Composition: Klhl3^tm1.1Slin/Klhl3^tm1.1Slin
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

increased systemic arterial systolic blood pressure ( J:284284 )

homeostasis/metabolism

acidemia ( J:284284 )

decreased circulating bicarbonate level ( J:284284 )

increased circulating aldosterone level ( J:284284 )

hyperkalemia ( J:284284 )

increased circulating chloride level ( J:284284 )

decreased urine potassium level ( J:284284 )

• mice show decreased fractional excretion of potassium

metabolic acidosis ( J:284284 )

• hyperchloremic metabolic acidosis

decreased renin activity ( J:284284 )

• secondary hyporeninemia

abnormal physiological response to xenobiotic ( J:284284 )

• mice show a blunted diuretic response to treatment with furosemide (NKCC2 inhibitor), showing decreased fractional excretion of sodium, potassium and chloride

• mice show an increased diuretic response to hydrochlorothiazide (NCC inhibitor), showing increased fractional excretion of sodium, potassium and chloride

renal/urinary system

decreased urine potassium level ( J:284284 )

• mice show decreased fractional excretion of potassium

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
pseudohypoaldosteronism		DOID:4479		J:284284