Phenotypes Associated with This Genotype

Genotype
MGI:6393456

• Allelic Composition: Spast^tm1.1Evre/Spast^tm1.1Evre
• Genetic Background: C57BL/6-Spast^tm1.1Evre

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

growth/size/body

decreased body weight ( J:253467 )

• mice are lighter at 1 year of age

behavior/neurological

abnormal gait ( J:253467 )

• gait abnormalities are seen at 4 months and 1 year of age

• mice show a lengthened mean stride duration, almost entirely due to elongation of the swing phase of gait

• however, mice have a symmetrical gait

long stride length ( J:253467 )

• mice show increased mean stride length

nervous system

abnormal axon morphology ( J:253467 )

• axon swellings of primary cortical neurons

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
hereditary spastic paraplegia 4		DOID:0110792	OMIM:182601	J:253467