Phenotypes Associated with This Genotype

Genotype
MGI:6393679

• Allelic Composition: Ezh2^tm1.1Nesh/Ezh2⁺; Cd19^tm1(cre)Cgn/Cd19⁺
• Genetic Background: involves: 129 * 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:239472 )

• median survival of 1 year

neoplasm

increased leukemia incidence ( J:239472 )

• about 50% of mice show frank leukemia and/or hepatic involvement

increased B cell derived lymphoma incidence ( J:239472 )

• mice develop B cell lymphoma with a median survival of 1 year

• tumors show a CD45+B220+CD19+IgM+CD43+CD5+ immunophenotype

• mice treated with JQEZ5, an S-5'adenosyl-l-methionine (SAM)-competitive pyridinone inhibitor, for 6 days show completely cleared malignant population from the spleen without depleting normal B cells

immune system

abnormal spleen morphology ( J:239472 )

• tumor-bearing mice show disruption of the splenic architecture

enlarged spleen ( J:239472 )

abnormal spleen white pulp morphology ( J:239472 )

• tumor-bearing mice show expansion of abnormal, large lymphoid cells in the white pulp

enlarged lymph nodes ( J:239472 )

hematopoietic system

abnormal spleen morphology ( J:239472 )

• tumor-bearing mice show disruption of the splenic architecture

enlarged spleen ( J:239472 )

abnormal spleen white pulp morphology ( J:239472 )

• tumor-bearing mice show expansion of abnormal, large lymphoid cells in the white pulp

growth/size/body

enlarged spleen ( J:239472 )

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
B-cell lymphoma		DOID:707		J:239472