Phenotypes Associated with This Genotype

Genotype
MGI:6393881

• Allelic Composition: Tmprss9^tm1.3Hzo/Tmprss9^tm1.3Hzo
• Genetic Background: involves: 129S1/Sv * C57BL/6J * C57BL/6NTac

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

abnormal object recognition memory ( J:284914 )

♀ • 1-year-old females show borderline deficits in the discrimination between novel and familiar objects, indicating minor recognition memory deficits

♀ • however, males and younger females show normal novel object recognition and mice exhibit normal fear memory in contextual and cued fear conditioning

increased thermal nociceptive threshold ( J:284914 )

♀ • 16-week-old females exhibit delayed pain response in the hot plate test

♀ • however, males and females at other ages do not exhibit nociception defects

abnormal social investigation ( J:284914 )

• in the 3-chamber interaction test, no difference is seen in the interaction time with the novel mouse versus an inanimate object compared to wild-type mice that show increased interaction with the novel mouse than the inanimate object in 13-week-old and 1-year-old mice

• however, mice do not exhibit repetitive behaviors, anxiety-like behaviors, motor learning and coordination deficits, or sensorimotor gating abnormalities

abnormal social recognition ( J:284914 )

• in the partition test, mice (females at 13 weeks and 1 year of age and males at 1 year of age) spend less time interacting with a novel mouse that replaces the familiar mouse than controls

growth/size/body

increased body weight ( J:284914 )

♀ • females, but not males, are heavier at 20 and 22 weeks but not at other time points from 3 to 26 weeks of age

nervous system

nervous system phenotype ( J:284914 )

N • no differences in overall brain cytoarchitecture are seen and in neuronal density in the hippocampus, cerebellum, and amygdala

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
autism spectrum disorder		DOID:0060041		J:284914