Phenotypes Associated with This Genotype

Genotype
MGI:6400455

• Allelic Composition: Dpp4^{tm1(DPP4)Vlcg}/?
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6NTac

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

lung inflammation ( J:223728 )

• mice infected with MERS-CoV intranasally show peribronchiolar inflammation at 2 days post infection

interstitial pneumonia ( J:223728 )

• mice infected with MERS-CoV intranasally show lung pathology consistent with development of interstitial pneumonia and lung disease

increased susceptibility to Coronaviridae infection ( J:223728 )

• mice support efficient infection and replication of the human Middle East respiratory syndrome coronavirus (MERS-CoV) , with mice developing peribronchiolar inflammation and lung pathology including peri-vascular cuffing and extensive alveolar thickening, and consistent with development of interstitial pneumonia and lung disease

• however, no viral RNA or inflammation is seen in the brain of MERS-CoV infected mice

• mice pretreated with REGN3051 or REGN3048, antibodies which bind to the MERS-CoV receptor-binding domain, show decreased viral levels and lung pathology after infection with MERS-CoV

• mice infected with MERS-CoV and then treated with REGN3051 at 24 hours after infection, show decreased viral levels and lung pathology

respiratory system

lung inflammation ( J:223728 )

• mice infected with MERS-CoV intranasally show peribronchiolar inflammation at 2 days post infection

interstitial pneumonia ( J:223728 )

• mice infected with MERS-CoV intranasally show lung pathology consistent with development of interstitial pneumonia and lung disease

thick pulmonary interalveolar septum ( J:223728 )

• mice infected with MERS-CoV intranasally develop extensive alveolar septum thickening at 4 dpi

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Middle East respiratory syndrome		DOID:0080642		J:223728