Phenotypes Associated with This Genotype

Genotype
MGI:6400998

• Allelic Composition: Nlgn1^em1Taku/Nlgn1^em1Taku
• Genetic Background: involves: C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:247060 )

N • mice show no differences in general locomotor activity, repetitive behavior, or anxiety-like behavior are seen, and show normal social behavior in the three-chamber social interaction test and the caged social interaction tests and normal ultrasonic vocalization

impaired spatial learning ( J:247060 )

• during the training phase of the Morris water maze test, mice show a mild but a significant delay of learning both in distance traveled and latency to reach goal

abnormal spatial reference memory ( J:247060 )

• in the probe trial of the Morris water maze test, mice show no difference between the time in target and opposite, and target and adjacent left quadrant indicating a modest impairment of spatial memory

decreased aggression towards mice ( J:247060 )

• in the tube test for social dominance, mice show a lower winning rate and more often retreat from wild-type mice

nervous system

nervous system phenotype ( J:247060 )

N • hippocampal neurons show normal spine numbers

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
autism spectrum disorder		DOID:0060041		J:247060