Phenotypes Associated with This Genotype

Genotype
MGI:6402037

• Allelic Composition: Gt(ROSA)26Sor^tm1Sor/Gt(ROSA)26Sor^tm1Sor; Tg(NPHS2-rtTA2*M2)1Jbk/Tg(NPHS2-rtTA2*M2)1Jbk; Tg(tetO-cre)LC1Bjd/Tg(tetO-cre)LC1Bjd
• Genetic Background: involves: 129S4/SvJaeSor * BALB/c * C57BL/6 * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

aneuploidy ( J:285673 )

• in primary podocyte cell cultures from doxycycline-treated mice

homeostasis/metabolism

increased urine protein level ( J:285673 )

• in doxycycline-treated mice

increased susceptibility to xenobiotic induced morbidity/mortality ( J:285673 )

• within the first 3 weeks following treatment with a high dose (50 ug/g) of doxycycline

• however, a lower doxycycline dose (15 ug/g) that produces FSGS does not affect lethality

mortality/aging

increased susceptibility to xenobiotic induced morbidity/mortality ( J:285673 )

• within the first 3 weeks following treatment with a high dose (50 ug/g) of doxycycline

• however, a lower doxycycline dose (15 ug/g) that produces FSGS does not affect lethality

renal/urinary system

increased urine protein level ( J:285673 )

• in doxycycline-treated mice

podocyte foot process effacement ( J:285673 )

• with vacuolization after 10 days in mice treated with doxycycline

decreased podocyte number ( J:285673 )

• reduced density in mice treated with doxycycline

glomerulosclerosis ( J:285673 )

• from 3 weeks of age, doxycycline-treated mice exhibit focal segmental glomerulosclerosis (FSGS) with adhesions, segmental accumulation of matrix, capillary hyalinosis, loss of capillaries, and declining glomerular numbers through 13 weeks unlike control mice

• however, mice do not develop FSGS when doxycycline is administered antenatally or at 10 and 11 days after birth or when mice are treated with a low dose of doxycycline (1.5 ug/g)

decreased renal glomerulus number ( J:285673 )

• in doxycycline-treated mice

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
focal segmental glomerulosclerosis		DOID:1312	OMIM:PS603278	J:285673