Phenotypes Associated with This Genotype

Genotype
MGI:6402819

ht2

• Allelic Composition: Otp^tm1Asim/Otp⁺
• Genetic Background: C3H.129P2(B6)-Otp^tm1Asim

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

adipose tissue

increased body fat mass ( J:251771 , J:251771 )

♀ • from age 8 weeks on regular chow (J:251771)

♂ • between age 6 and 12 and at 18 weeks on regular chow (J:251771)

growth/size/body

increased body fat mass ( J:251771 , J:251771 )

♀ • from age 8 weeks on regular chow (J:251771)

♂ • between age 6 and 12 and at 18 weeks on regular chow (J:251771)

increased lean body mass ( J:251771 , J:251771 )

♀ • from age 10 weeks on regular chow (J:251771)

♂ • from age 6 weeks on regular chow (J:251771)

obese ( J:251771 )

homeostasis/metabolism

increased circulating leptin level ( J:251771 )

• at age 8 and 12 weeks on regular chow after 5-6h fast

impaired glucose tolerance ( J:251771 )

• at age 12 weeks on regular chow after 5-6h fast

insulin resistance ( J:251771 , J:251771 )

♀ • no insulin resistance at age 12 weeks on regular chow after 5-6h fast (J:251771)

♂ • at age 12 weeks on regular chow after 5-6h fast (J:251771)