Analysis Tools
skeleton
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• ectopic ossification at age 18 weeks
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• ectopic ossification at age 12 weeks
• hypercalcification and rigidity in almost all movable joints at age 18 weeks
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• hypercalcification and rigidity in almost all movable joints at age 18 weeks
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• progressive ankylosis of the fore-limbs with aging starting at age 3 weeks and at age 12 weeks
• hypercalcification and rigidity in almost all movable joints at age 18 weeks
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• tiptoe walking as result of progressive ankylosis of the fore-limbs with aging starting at age 3 weeks
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• volume increased with age
• herniation into posterior and anterior regions
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fused joints
(
J:250073
)
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• progressive ankylosis of the fore-limbs with aging starting at age 3 weeks and at age 12 weeks
• hypercalcification and rigidity in almost all movable joints at age 18 weeks
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• marked deposition of calcium in intervertebral spaces, especially at both edges of vertebral bodies at age 18 weeks
• hypercalcification and rigidity in almost all movable joints at age 18 weeks
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• marked deposition of calcium in intervertebral spaces, especially at both edges of vertebral bodies at age 18 weeks
• hypercalcification and rigidity in almost all movable joints at age 18 weeks
• degeneration and destruction of cartilage matrix from age 8 weeks
• lateral protrusion in intervertebral discs from age 8 weeks
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• endochondral ossification of cartilaginous cells in anterior and posterior longitudinal ligament at age 18 weeks
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• endochondral ossification of cartilaginous cells at age 18 weeks
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limbs/digits/tail
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• ectopic ossification at age 12 weeks
• hypercalcification and rigidity in almost all movable joints at age 18 weeks
|
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• progressive ankylosis of the fore-limbs with aging starting at age 3 weeks and at age 12 weeks
• hypercalcification and rigidity in almost all movable joints at age 18 weeks
|
|
• tiptoe walking as result of progressive ankylosis of the fore-limbs with aging starting at age 3 weeks
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integument
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• ectopic ossification of whisker follicles at age 18 weeks
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• ectopic ossification of whisker follicles at age 18 weeks
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mortality/aging
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• first signs of mortality at age 100 days; median survival 118 days; all mice dead by age 220 days
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growth/size/body
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• ectopic ossification at age 18 weeks
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weight loss
(
J:250073
)
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• significantly reduced body weight from age 12 weeks
• normal body weight at age 4 and 8 weeks
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behavior/neurological
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• significantly reduced from age 12 weeks
• normal at age 4 and 8 weeks
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adipose tissue
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• normal at age 8 weeks
• significantly reduced from age 12 weeks
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• in visceral fat at age 16 weeks
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hearing/vestibular/ear
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• ectopic ossification at age 18 weeks
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nervous system
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• compression of spinal cord caused by vertebral ossification
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craniofacial
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• ectopic ossification at age 18 weeks
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| ossification of the posterior longitudinal ligament of spine | DOID:0060887 |
OMIM:602475 |
J:250073 | |
