Phenotypes Associated with This Genotype

Genotype
MGI:6403685

cn4

• Allelic Composition: Brf1^tm1Arte/Brf1^tm1Arte; Tg(Cyp1a1-cre)1Dwi/0
• Genetic Background: involves: C57BL/6 * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

liver/biliary system

increased hepatocyte apoptosis ( J:285667 )

liver inflammation ( J:285667 )

small liver ( J:285667 )

• at P8

hepatic necrosis ( J:285667 )

homeostasis/metabolism

abnormal translation ( J:285667 )

• reduce in polysome loading at P4 in the liver due to shortage of tRNA

• absent polysome at P8

immune system

liver inflammation ( J:285667 )

cellular

increased hepatocyte apoptosis ( J:285667 )

abnormal translation ( J:285667 )

• reduce in polysome loading at P4 in the liver due to shortage of tRNA

• absent polysome at P8