Phenotypes Associated with This Genotype

Genotype
MGI:6403905

• Allelic Composition: Stat1^tm1Dlv/Stat1^tm1Dlv; Tg(ANPEP)861Mmul/Tg(ANPEP)861Mmul
• Genetic Background: involves: 129S/SvEv * ICR

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

increased susceptibility to Coronaviridae infection ( J:99728 )

• mice inoculated through oral, intranasal, intragastic and intraperitoneal routes with an adapted human coronavirus 229E (HCoV-229E) that was produced by propagating the virus for 4 passages at 37 degrees Celsius on primary embryonic fibroblasts (HCoV-229E-37) are permissive to infection, showing large amounts of virus in the lungs and the gut, and also in the spleen and liver, with mice surviving at least 18 days after infection, showing a mild loss of weight and slight temperature increase, and hemorrhaging areas in lung and small intestines

• mice administered HCoV-229E-37 through the nasal rout show virus growth in the lung but not in the gut, liver or spleen

cardiovascular system

lung hemorrhage ( J:99728 )

• mice challenged with HCov-229E-37 by the different routes show hemorrhaging areas in the lung, mainly between 2 and 4 days post infection

small intestine hemorrhage ( J:99728 )

• mice challenged with HCov-229E-37 by the different routes show hemorrhaging areas in the small intestine, mainly between 2 and 4 days post infection

respiratory system

lung hemorrhage ( J:99728 )

• mice challenged with HCov-229E-37 by the different routes show hemorrhaging areas in the lung, mainly between 2 and 4 days post infection

digestive/alimentary system

small intestine hemorrhage ( J:99728 )

• mice challenged with HCov-229E-37 by the different routes show hemorrhaging areas in the small intestine, mainly between 2 and 4 days post infection

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Coronavirus infectious disease		DOID:0080599		J:99728