Phenotypes Associated with This Genotype

Genotype
MGI:6405398

• Allelic Composition: Tardbp^tm1.1Neas/Tardbp^tm1.1Neas
• Genetic Background: B6(C3)-Tardbp^tm1.1Neas

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

nervous system phenotype ( J:283769 )

N • no motor neuron loss is seen in the L4-5 spinal cord at 1, 1.5 or 2 years of age and no TDP-43 aggregation in ChAT+ neurons is seen in the lumbar spinal cord

microgliosis ( J:283769 )

• 2 year old mice show microgliosis in the lumbar spinal cord

astrocytosis ( J:283769 )

• 2 year old mice show astrocytosis in the lumbar spinal cord

abnormal motor neuron innervation pattern ( J:283769 )

• denervation of the tibialis anterior muscle is seen at around 2.5 years of age but not 2 years, with asymmetric innervation of the tibialis anterior muscle and mice with the most denervation also showing the highest degree of asymmetry

immune system

microgliosis ( J:283769 )

• 2 year old mice show microgliosis in the lumbar spinal cord

hematopoietic system

microgliosis ( J:283769 )

• 2 year old mice show microgliosis in the lumbar spinal cord

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
amyotrophic lateral sclerosis type 10		DOID:0060201	OMIM:612069	J:283769