nervous system
N |
• no motor neuron loss is seen in the L4-5 spinal cord at 1, 1.5 or 2 years of age and no TDP-43 aggregation in ChAT+ neurons is seen in the lumbar spinal cord
|
microgliosis
(
J:283769
)
• 2 year old mice show microgliosis in the lumbar spinal cord
|
astrocytosis
(
J:283769
)
• 2 year old mice show astrocytosis in the lumbar spinal cord
|
• denervation of the tibialis anterior muscle is seen at around 2.5 years of age but not 2 years, with asymmetric innervation of the tibialis anterior muscle and mice with the most denervation also showing the highest degree of asymmetry
|
immune system
microgliosis
(
J:283769
)
• 2 year old mice show microgliosis in the lumbar spinal cord
|
hematopoietic system
microgliosis
(
J:283769
)
• 2 year old mice show microgliosis in the lumbar spinal cord
|
Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
amyotrophic lateral sclerosis type 10 | DOID:0060201 |
OMIM:612069 |
J:283769 |