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Phenotypes Associated with This Genotype
Genotype
MGI:6406400
cx1
Allelic
Composition
Chn1tm1.2Ece/Chn1tm1.2Ece
Tg(Hlxb9-GFP)1Tmj/0
Genetic
Background
involves: 129S1/Sv * 129S6/SvEvTac * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Chn1tm1.2Ece mutation (0 available); any Chn1 mutation (44 available)
Tg(Hlxb9-GFP)1Tmj mutation (3 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• abducens nerve exits with an increased number of defasciculated bundles within the hindbrain, some of which wander dorsally toward the hindbrain or ventrally to track along the developing buccal branch of the facial nerve
• however, a subset of abducens nerve bundles successfully fasciculate within the midway between the hindbrain and orbit and innervate the extraocular muscle anlage at the orbit
• trochlear nerve and first spine projections are unaffected
• abducens nerve diameter is greater
• however, abducens nerve length is normal

vision/eye
N
• mice do not exhibit globe retraction and do not have Duane retraction syndrome


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
12/10/2024
MGI 6.24
The Jackson Laboratory