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Phenotypes Associated with This Genotype
Genotype
MGI:6406417
cx3
Allelic
Composition
Chn1tm1.2Ece/Chn1+
Epha4tm1.2Bzh/Epha4tm1.2Bzh
Tg(Hlxb9-GFP)1Tmj/0
Genetic
Background
involves: 129S/Sv * C57BL/6J * CD-1 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Chn1tm1.2Ece mutation (0 available); any Chn1 mutation (44 available)
Epha4tm1.2Bzh mutation (0 available); any Epha4 mutation (67 available)
Tg(Hlxb9-GFP)1Tmj mutation (3 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• while embryos show normalized abducens exit and fasciculation, abducens nerve stalling is increased in the abducens fasciculation region, with both reduced abducens nerve length and thinner nerve diameter near the orbit
• stalled projections do not stay within normal nerve boundaries and instead wander to track with the mandibular and cervical branches of the facial nerve
• abducens nerve length is reduced in embryos and nerve diameter is thinner near the orbit


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
12/10/2024
MGI 6.24
The Jackson Laboratory