About   Help   FAQ
Phenotypes Associated with This Genotype
Genotype
MGI:6414964
Allelic
Composition		 Acvr1tm1Mak/Acvr1+
Gt(ROSA)26Sortm1(Pik3ca*H1047R)Egan/Gt(ROSA)26Sor+
Olig2tm1.1(cre)Wdr/Olig2+
Genetic
Background		 involves: 129 * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Acvr1tm1Mak mutation (0 available); any Acvr1 mutation (44 available)
Gt(ROSA)26Sortm1(Pik3ca*H1047R)Egan mutation (2 available); any Gt(ROSA)26Sor mutation (993 available)
Olig2tm1.1(cre)Wdr mutation (1 available); any Olig2 mutation (46 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased brain tumor incidence ( J:285841 )
• most mice succumb to spontaneous brain tumors
increased glioma incidence ( J:285841 )
• tumors are high-grade diffuse gliomas

nervous system
increased brain tumor incidence ( J:285841 )
• most mice succumb to spontaneous brain tumors
increased glioma incidence ( J:285841 )
• tumors are high-grade diffuse gliomas

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
brain glioma DOID:0060108 J:285841

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory