Phenotypes Associated with This Genotype

Genotype
MGI:6415731

• Allelic Composition: Scn5a^em1Coop/Scn5a⁺
• Genetic Background: involves: FVB/NJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

irregular heartbeat ( J:279087 )

• intracardiac pacing shows that mice are susceptible to inducible arrhythmias

abnormal impulse conducting system conduction ( J:279087 )

• optical mapping shows delays in activation and propagation of conduction, a trend of prolonged action potential duration, and decreased ventricular conduction velocity

• however, mice show no differences in ejection fraction, fractional shortening, or morphological differences, indicating that contractility is not affected

atrioventricular block ( J:279087 )

• pacing in hearts shows atrioventricular block

prolonged QRS complex duration ( J:279087 )

abnormal QT interval ( J:279087 )

• variability in corrected QT interval

abnormal sinoatrial node conduction ( J:279087 )

• in vivo intracardiac pacing on anesthetized mutants shows prolonged atrioventricular effective refractory period

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
sick sinus syndrome		DOID:13884	OMIM:163800 OMIM:608567	J:279087