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Phenotypes Associated with This Genotype
Genotype
MGI:6416491
Allelic
Composition
Tg(FGFR3-G380R)7Aya/0
Genetic
Background
involves: BALB/c * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
growth/size/body
• narrow thorax

skeleton
• slightly larger skull
• 16% shortening of the femur
• 9% shortening of the tibia
• some irregularly arranged chondrocytes are seen along the columns
• some mice show foci of vascularization and transverse tunneling of the cartilage in the growth plate
• growth plates in 1-week old mice exhibit decreased cell proliferation
• shorter chondrocyte columns with less proliferative cells
• shorter chondrocyte columns with less proliferative and hypertrophic cells
• growth plates of distal bones are less affected
• older mice show a marked reduction in the column size of growth plates due to less proliferating and hypertrophic chondrocytes
• narrowing of the spinal column
• mice show a delay in chondrocyte maturation, delay in chondrocyte terminal differentiation within the secondary ossification centers (replacement of cartilage by bone and vascular invasion within secondary ossification centers is not seen at 2 months of age), and a delay in mineralization

craniofacial
• slightly larger skull

limbs/digits/tail
• 16% shortening of the femur
• 9% shortening of the tibia
• mild shortening and broadening of extremities, particularly the proximal segments of long bones

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
achondroplasia DOID:4480 OMIM:100800
J:59887


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
12/10/2024
MGI 6.24
The Jackson Laboratory