Analysis Tools
behavior/neurological
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• mice exhibit reduced freezing responses in contextual fear conditioning
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• mice show reduced freezing responses in cued fear conditioning
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• mice show reduced immobility in the forced swim test
• however, mice show no alteration in the tail suspension test, with mice spending a similar immobile time as wild-type mice
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• in the elevated plus maze, mice show increased counts of open arm entries without alternations in the time spent in the open arms indicating slightly reduced levels of anxiety
• in the light/dark box, mice show an increase in exploration distance in the light zone compared to wild-type mice, however, mice do not enter the light zone more often than wild-type mice, indicating slightly reduced levels of anxiety
• however, mice do not show differences in the novelty-suppressed feeding test, indicating no anxiety-related reduced behavior in response to a novel environment
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• mice exhibit reduced freezing responses in the contextual and cued fear conditioning
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• mice do not at all engage in digging behavior, leaving most marbles in their place, although they interact with the marble by sniffing or trying to bite them
• mice exhibit normal nesting behavior, utilizing the nestlets similarly to wild-type mice, however they show reduced nestlet shredding
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• in the 3-chamber sociability test, mice show reduced sociability, with mice spending only slightly more time interacting with the stranger mouse than with the inanimate object
• however, mice show no apparent changes in the response to social novelty
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taste/olfaction
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• mice exhibit normal olfaction in the buried food test
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| disease of mental health | DOID:150 | J:286038 | ||
