Phenotypes for Prph2 MGI:6423341 MGI Mouse

vision/eye

abnormal ocular fundus morphology ( J:215646 )

• widespread yellow flecks are seen in the fundus at P180

• however, no changes in retinal vasculature are seen at P180

abnormal photoreceptor outer segment morphology ( J:215646 )

• small rounded outer segment structures are seen at P30 that disappear by P180

• outer segment formation initiates, however structures are small at P30 and outer segments do not exhibit normal discs/lamellae but do have flattened, whorl shaped membranes

• many abnormal vesicular structures line up adjacent to the flattened discs

abnormal photoreceptor outer segment disc membrane morphology ( J:215646 )

• abnormal disc sizing

• misorientation of outer segment discs in relation to each other and the axoneme/connecting cilium

retina photoreceptor degeneration ( J:215646 )

• photoreceptor degeneration is severe by P180

retina outer nuclear layer degeneration ( J:215646 )

• small reduction in the outer nuclear layer thickness at P30 and by P180, the outer nuclear layer is thin in the central retina and almost absent in the periphery

decreased a-wave amplitude ( J:215646 )

• scotopic a wave amplitude is reduced at P30 and P180

decreased b-wave amplitude ( J:215646 )

• scotopic b wave amplitude is reduced at P30 and P180

• photopic b wave amplitude is reduced at P30 and P180

abnormal cone electrophysiology ( J:215646 )

• photopic ERG responses are lower

abnormal rod electrophysiology ( J:215646 )

• scotopic responses are reduced at P30 and P180, with no mice exhibiting an a-wave above the limit of detection

nervous system